Immunohistochemical study on contents of beta-amyloid, alpha-actin and collagen IV in cerebral small vessels with unknown type of pathological lesion.
- Author:
Min ZHANG
1
;
Da-wei GUAN
;
Rui ZHAO
;
Geng-yi HU
;
Yang HAN
;
Zhen-huan HOU
;
Ya-ming SHAN
Author Information
1. Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China. zm_123@sina.com
- Publication Type:Journal Article
- MeSH:
Actins/metabolism*;
Amyloid beta-Peptides/metabolism*;
Autopsy;
Blood Vessels/ultrastructure*;
Brain/pathology*;
Cerebral Amyloid Angiopathy/pathology*;
Collagen Type IV/metabolism*;
Humans;
Image Processing, Computer-Assisted;
Immunohistochemistry;
Staining and Labeling;
Subarachnoid Hemorrhage/pathology*
- From:
Journal of Forensic Medicine
2006;22(6):413-416
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the structural characteristics of the cerebral small vessels with an unknown type of pathological lesion (UTPL).
METHODS:Contents of beta-amyloid, alpha-actin and collagen IV in cerebral small vessels with UTPL were studied by Congo red staining, immunohistochemical staining and computer image analysis.
RESULTS:The low expression levels of alpha-actin and collagen IV (P<0.05) were observed in tunica media of the vessels with UTPL, and no positive expression of beta-amyloid (P>0.05) was observed in these vessel walls. The expressions of proteins mentioned above in UTPL were different from those of cerebral amyloid angiopathy(CAA) and hyaline arteriolosclerosis.
CONCLUSION:UTPL was different from CAA or hyaline arteriolosclerosis in pathologic feature.
