Determination of methamphetamine in whole blood by capillary zone electrophoresis after solid phase extraction.
- Author:
Fei-Jun GONG
1
;
Run-Sheng ZHANG
Author Information
1. Shanghai Institute of Criminal Science and Technology, Shanghai 200083, China.
- Publication Type:Journal Article
- MeSH:
Doxapram/chemistry*;
Electrophoresis, Capillary/methods*;
Forensic Medicine;
Gas Chromatography-Mass Spectrometry;
Humans;
Methamphetamine/poisoning*;
Reproducibility of Results;
Sensitivity and Specificity;
Solid Phase Extraction;
Solvents/chemistry*
- From:
Journal of Forensic Medicine
2006;22(5):353-354
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To develop a specific CZE method for the determination of methamphetamine in whole blood after solid phase extraction.
METHODS:With the doxapram as internal standard, Oasis column was used to extract drugs from whole blood and the sample was analysized by CZE.
RESULTS:The method showed excellent linearity and the linear correlation coefficient was 0.994. The relative standard deviation for between-day and within-day were 5.31% and 2.22%, respectively.
CONCLUSION:The method is effective, simple, reliable and has been used in the determination of methamphetamine in whole blood.
