Dynamic observation of brainstem auditory evoked potential and pathological changes of the brain after closed brain injuries in rats.
- Author:
Jing-Ji WU
1
;
Ming LIU
;
Hong-Tao YAN
;
Zhong ZHENG
;
Ye WANG
;
Bin LI
;
Zhi-Gang LIAO
Author Information
1. Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. wjj972@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Auditory Perceptual Disorders/etiology*;
Brain/pathology*;
Brain Edema/pathology*;
Brain Injuries/physiopathology*;
Brain Stem/physiopathology*;
Disease Models, Animal;
Evoked Potentials, Auditory, Brain Stem/physiology*;
Male;
Random Allocation;
Rats;
Rats, Sprague-Dawley
- From:
Journal of Forensic Medicine
2006;22(5):324-327
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the dynamic experiences of pathological changes in brain and the injured role of brainstem auditory evoked potential (BAEP) after closed Mild Traumatic Brain Injury (MTBI) in rat.
METHODS:A closed diffuse brain injury model was successfully produced in rat by hit the parietal bone with a spring-droved steel stick. The auditory brainstem response evoked by click at 50Hz stimulating frequency were recorded at pre-trauma, 15 min and 1, 3, 6, 12 h and 1, 2, 4, 7, 10, 14, 21 d after brain injury. The pathological changes of brain were observed under light microscope and the brain edema was detected by wet weight/dry weight rations.
RESULTS:The I-V, III-V of BAEP wave inter peak latency (IPL) in MTBI group increased immediately in 15 minutes after injury. The III, V wave peak latency (PL) and I-V, III-V wave IPL became longer than the pre-trauma level in 6, 12 h post-injury (P<0.05). The III, V wave PL and I - III, I - V, III - V wave IPL became longer than the pre-trauma level in 1, 2 d after injury (P < 0.001), the BAEP retuned to normal level in 14 d after brain injury. At 15 minutes after injury, the water content in brain increased and met its peak in 1 d, decreased gradually in 4 d, then decreased slowly and returned to normal level in 10 d after injury.
CONCLUSION:The regular changes of BAEP could be an objective tool for evaluating hearing dysfunction after closed mild diffuse traumatic brain injury.
