Development of a gas chromatography-mass spectrometry method for the quantification of propofol in blood.
- Author:
You-Jiang ZHU
1
;
Xuan-Kun DING
Author Information
1. The people's Procuratorate of Huzhou, Huzhou 313000, China.
- Publication Type:Journal Article
- MeSH:
Anesthetics, Intravenous/blood*;
Gas Chromatography-Mass Spectrometry/methods*;
Humans;
Propofol/blood*;
Reproducibility of Results;
Sensitivity and Specificity
- From:
Journal of Forensic Medicine
2006;22(4):313-314
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:A rapid and selective method has been developed for the determination of propofol in blood by gas chromatography-mass spectrometry (GC-MS).
METHODS:The blood was extrasted with the solution of internal standard, the extracted residue was analyzed by gas chromatography-mass spectrometry using selected-ion monitoring mode.
RESULTS:The linear range was 0.1-10 microg/mL. The coefficient(R2) was 0.993 1. The detection limit was 0.05 microg/mL.
CONCLUSION:The method is simple and rapid, offering superior sensitivity and selectivity for propofol. The method can be used successfully during clinical and forensic toxicology.
