Changes of cyclin D1 expression following human brain contusion.
- Author:
Yi-Wu ZHOU
1
;
Ai-Wu XIAO
;
Wei-Nian DENG
;
Lai-Jing SUN
;
Xi-Ji SHU
;
Jia-Pei DAI
;
Liang LIU
;
Xiao-Hu XU
Author Information
1. Department of Forensic Medicine, Shantou Medical College, Shantou University, Shantou 515031, China. yiwuhedi@hotmail.com
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Adolescent;
Adult;
Aged;
Astrocytes/metabolism*;
Brain/pathology*;
Brain Injuries/pathology*;
Cyclin D1/metabolism*;
Female;
Humans;
Immunohistochemistry;
Male;
Middle Aged;
Neuroglia/metabolism*;
Staining and Labeling;
Time Factors;
Young Adult
- From:
Journal of Forensic Medicine
2006;22(4):245-250
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the relationships of Cyclin D1 expression with the posttraumatic intervals (PTI) following the cerebra, brainstem or cerebella contusion in human.
METHODS:88 cases of brain contusions of the closed head injury were investigated with pathological and Cyclin D1 immunohistochemistry methods. The results were analyzed by image analysis technique (IAT).
RESULTS:The immunoreactivity of Cyclin D1 was almost disappeared in the core cells of the brain contusion. Cyclin D1-positive cells started to increase in the boundary of the brain contusion in the 1h group. Cyclin D1-positive cells were increased significantly in the 3 h-30 d groups and maintained at a high level in the boundary of the brain contusion of those groups. It is suggested that the Cyclin D1-positive cells were primarily origin from microglia and other glia. A few neurons expressed Cyclin D1.
CONCLUSION:Cyclin D1 can express in several kinds of brain cells following the contusion, especially in the glia cells. Cyclin D1-positive cells were increased obviously and rapidly after injury, so it could be used as a reference marker for early stage brain injury.
