Haplotypes of DXS10011 and DXS8377 in Guangdong Han individuals.
- Author:
De-Jian LU
1
;
Shu-Chun CHEN
;
Xue-Wen WANG
;
Qiu-Ling LIU
;
Hui-Ling LU
Author Information
1. Department of Forensic Serology, Zhongshan-Medical College, Sun Yat-sen University, Guangzhou 510089, China. dejian6182@sina.com
- Publication Type:Journal Article
- MeSH:
Alleles;
Asian People/genetics*;
China;
Chromosomes, Human, X/genetics*;
DNA/genetics*;
Electrophoresis, Polyacrylamide Gel;
Forensic Sciences;
Gene Frequency;
Genetic Linkage;
Haplotypes;
Humans;
Male;
Paternity;
Polymerase Chain Reaction;
Polymorphism, Genetic;
Tandem Repeat Sequences
- From:
Journal of Forensic Medicine
2006;22(3):207-209
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate genetic polymorphism of two X chromosome specific STR: DXS10011 and DXS8377 in male samples from Guangdong Han population.
METHODS:The DNA samples were amplified by PCR and analyzed by polyacrylamide gel electrophoresis followed by silver staining.
RESULTS:Among 113 samples, 20 alleles were found for DXS1011 and 12 alleles for DXS8377. Also, 72 DXS10011-DXS8377 haplotypes were shown. The most common haplotypes only occurred three times. When only female children were tested in motherless case, the exclusion probability of paternity was 0.9588 for DXS10011-DXS8377 haplotypes. Investigations in 83 family trios with female children and 29 pedigrees with two children suggested a co-dominant X-linked inheritance; mutations were not found.
CONCLUSION:Our data indicate that DXS10011 and DXS8377 are highly informative X chromosome markers for complicated kinship analysis.
