Experimental pathological study of acute intoxication by Chloranthus serratus Roem. Et Schalt.
- Author:
Wu ZHANG
1
;
Jian-hua ZHU
;
Li-bao CHENG
;
Yong-hong LI
Author Information
1. Department of Forensic Pathology,Wannan Medical College, Wuhu 241001,China.
- Publication Type:Journal Article
- MeSH:
Animals;
Biomarkers/blood*;
Dose-Response Relationship, Drug;
Endoplasmic Reticulum/drug effects*;
Female;
Forensic Pathology;
Kidney/pathology*;
Lethal Dose 50;
Liver/pathology*;
Magnoliopsida/chemistry*;
Male;
Mice;
Mitochondria, Heart/drug effects*;
Mitochondria, Liver/drug effects*;
Myocardium/pathology*;
Plant Extracts/toxicity*;
Random Allocation
- From:
Journal of Forensic Medicine
2006;22(1):15-17
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To find out the pathological change and the toxic mechanism of Chloranthus serratus Roem. et Schalt in mice.
METHODS:Mice were intoxicated by oral administration with extracts of Chloranthus serratus Roem. et Schalt followed by pathological, serum biochemical, and coagulation mechanism examination.
RESULTS:The LD50 in mice was 41.12 g/kg; All poisoned mice serum BUN and ALT increased markedly; Thrombocyte decreased and coagulation time increased; The organ index of liver, spleen and kidneys increased significantly; The cells of liver, kidney and heart were degeneration and necrosis, There were extensive hyperemia and hemorrhage in many organs.
CONCLUSION:The experiment suggests that the target organs were liver, kidney, heart and blood vessels; The toxic mechanism was the damage on the mitochondrional, endoplasmic reticulum and coagulation system.
