The expression of COX-1 and COX-2 following brain injuries.
- Author:
Xue-rong GUO
1
;
Yi-wu ZHOU
;
Yi-lie MA
Author Information
1. Faculty of Forensic Medicine, Huazhong University of Science & Technology, Wuhan 430030, China.
- Publication Type:Review
- MeSH:
Animals;
Apoptosis/drug effects*;
Brain Injuries/pathology*;
Cyclooxygenase 1/metabolism*;
Cyclooxygenase 2/metabolism*;
Cyclooxygenase Inhibitors/therapeutic use*;
Humans;
Immunohistochemistry;
Neurons/drug effects*;
Rats;
Time Factors
- From:
Journal of Forensic Medicine
2005;21(3):223-225
- CountryChina
- Language:Chinese
-
Abstract:
Cyclooxygenase (COX) is the obligate, rate-limiting enzyme for the conversion of arachidonic acid into prostaglandins, which mediate mitogenesis, apoptosis, angiogenesis, blood flow, secondary injury, and inflammation. COX is consist of 2 subtypes: COX-1 and COX-2. In recent years, there are a number of lines of evidence that COX-1 and COX-2 play a important in role brain injuries.
