Lethal anaphylactic shock model induced by human mixed serum in guinea pigs.
- Author:
Guang-Mu REN
1
;
Ji-Wei BAI
;
Cai-Rong GAO
Author Information
1. Department of forensic medicine,Shanxi Medical University, Taiyuan 030001, China. renguangmu@163.com
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Allergens;
Anaphylaxis/immunology*;
Animals;
Death, Sudden;
Disease Models, Animal;
Female;
Forensic Medicine;
Guinea Pigs;
Humans;
Immunoglobulin G/blood*;
Male;
Radioimmunoassay;
Random Allocation;
Serum/immunology*
- From:
Journal of Forensic Medicine
2005;21(3):169-170
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish an anaphylactic shock model induced by human mixed serum in guinea pigs.
METHODS:Eighteen guinea pigs were divided into two groups: sensitized and control, The sensitized group were immunized intracutaneously with human mixed serum and then induced by endocardiac injection after 3 weeks.
RESULTS:Symptoms of anaphylactic shock appeared in the sensitized group. The level of serum IgE were increased in the sensitized group significantly.
CONCLUSIONS:An animal model of anaphylactic shock wer established successfully. It provide a tool for both forensic study and anaphylactic shock therapy.
