The study developments about changes of methamphetamine-induced genes' transcriptions and translations.
- Author:
Jing YANG
1
Author Information
1. West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
- Publication Type:Review
- MeSH:
Animals;
Circadian Rhythm/genetics*;
Forensic Medicine;
Gene Expression Regulation/drug effects*;
Humans;
Methamphetamine/pharmacology*;
Neocortex/metabolism*;
Neurons/pathology*;
Proto-Oncogene Proteins c-bcl-2/metabolism*;
Proto-Oncogene Proteins c-fos/metabolism*;
Substance-Related Disorders;
Transcription, Genetic/drug effects*;
Translocation, Genetic/drug effects*
- From:
Journal of Forensic Medicine
2004;20(3):185-188
- CountryChina
- Language:Chinese
-
Abstract:
The basic changes are to transform the levels of many genes' transcriptions and translations when methamphetamine is injected into the organism. Those genes enclose four classes: genes intermediating the damages or death of neurons,genes involving circadian rhythms of activity, genes concerning the abnormality of behaviors and some genes difficult to be classified. The transformations of the transcriptions or translations of these genes cooperate to produce many clinic syndromes of methamphetamine-addictors. Moreover, the study of these genes can provide testimonies to forensic identification.
