Study on the changes of electrocardiogram and ultrastructural in heroin dependence in rats.
- Author:
Xiao-shan LIU
1
;
Yu-chuang CHEN
;
Zhao-hui LI
Author Information
1. Department of Forensic Medicine, Medical Center of Zhongshan University, Guanzhou 510080, China. lxsa@gzsums.edu.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Disease Models, Animal;
Electrocardiography;
Heart Rate;
Heroin Dependence/physiopathology*;
Myocardial Ischemia/physiopathology*;
Myocardium/ultrastructure*;
Rats;
Rats, Sprague-Dawley
- From:
Journal of Forensic Medicine
2004;20(3):129-135
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the changes of electrocardiograms (ECG) and myocardial ultrastructure in heroin dependence in rats, in order to reveal the mechanisms of the myocardial injury by heroin.
METHODS:Establish heroin addict model in SD mice, investigate the changes in electrocardiograms, HE staining and myocardial ultrastructure.
RESULTS:The electrocardiograms of the addict group had prominently changes, main expressions: heart rate decreased, P wave and T wave amplitude reduced and duration increased, S-T reduced and duration increased, QT interval prolongation, these changes indicated that myocardium had been injured, myocardial ischemia, ventricle function declined. These difference was significant (P<0.05) between before inject heroin and after inject heroin. Transformations in the ultrastructure: nuclear concentrate, reduce, nuclear membrane shrink, chromatin agglutinate, mitochondria cristal had disorder formation, disappeared or hollowed, these indicated that heroin could cause pathological changes in myocardial ultrastructure.
CONCLUSION:Above-mentioned changes indicated that heroin can injure myocardium, and the changes of myocardial ultrastructure suggested that myocardial apoptosis may be one of the mechanisms of the myocardial injury by heroin.
