Immunohistochemical observation of heart-type fatty acid binding-protein in early myocardial ischemia.
- Author:
Mei MING
1
;
Xiang-zhi MENG
Author Information
1. Department of Forensic Medicine, School of Medicine, Wuhan University, Wuhan 430071, China. monkmm@sina.com
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Biomarkers/analysis*;
Carrier Proteins/analysis*;
Creatine Kinase/blood*;
Enzyme-Linked Immunosorbent Assay;
Fatty Acid-Binding Proteins;
Humans;
Immunohistochemistry;
Myocardial Ischemia/metabolism*;
Myocardium/pathology*;
Myoglobin/metabolism*;
Sensitivity and Specificity
- From:
Journal of Forensic Medicine
2004;20(1):15-17
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:The sensitivity of heart-type fatty acid binding-protein (H-FABP) in the postmortem diagnosis of myocardial ischemia was explored.
METHODS:The changes of H-FABP staining in normal, infarcted and suspected ischemia of myocardial cells were studied by immunohistochemistry.
RESULTS:There was no depletion in normal control group, and obvious depletion was observed in myocardial infarcted group. Among 9 suspected myocardial ischemia group, 3 cases showed obvious depletion and 3 cases showed vague depletion for H-FABP, there were obvious depletion of Mb in 4 suspected myocardial ischemia cases and vague depletion in 2 cases for Mb. It is indicated that H-FABP can be used to diagnose early myocardial ischemia.
CONCLUSION:H-FABP is quite sensitive and useful for the diagnosis of early myocardial ischemia.
