A study on the expression of VEGF in the blunt injury of rat's skin.
- Author:
Mei LI
1
;
Pei-jun HUANG
;
Min LIU
Author Information
1. Forensic Pathology Department, School of Legal Medicine, Sichuan University, Chengdu 610041. lmei@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Endothelial Growth Factors/metabolism*;
Female;
Forensic Medicine;
Intercellular Signaling Peptides and Proteins/metabolism*;
Lymphokines/metabolism*;
Male;
Rats;
Rats, Sprague-Dawley;
Skin/metabolism*;
Time Factors;
Vascular Endothelial Growth Factor A;
Vascular Endothelial Growth Factors;
Wounds, Nonpenetrating/metabolism*
- From:
Journal of Forensic Medicine
2003;19(1):13-15
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate changes of VEGF in skin after blunt injury.
METHODS:The rats of injury groups were subjected to skin blunt injury by free-falling iron hammer. The samples taken at 1 h, 3 h, 6 h, 12 h, 1 d, 3 d, 5 d, 7 d, 9 d after injury were studied by immunohistochemistry and MIAS image analysis system.
RESULTS:In the skin of normal control group the expression level of VEGF was low. The increase of VEGF could be observed at 1 day after injury, reached peak at 7 days and declined at 9 days.
CONCLUSION:Blunt injury in the skin could induce the expression of the VEGF. Moreover, the change pattern of VEGF level was quite regular with time and could be used to estimate the time after skin injury.
