A study on the expression of C-FOS protein after experimental rat brain concussion.
- Author:
Feng WANG
1
;
Yong-hong LI
;
Yong-liang HU
Author Information
1. Department of Forensic Medicine, Wannan Medical College, Wuhu 241001. wangfeng760914@Sohu.com
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Animals;
Biomarkers;
Brain Concussion/metabolism*;
Female;
Forensic Medicine;
Immunohistochemistry;
Male;
Proto-Oncogene Proteins c-fos/genetics*;
RNA, Messenger/genetics*;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Time Factors
- From:
Journal of Forensic Medicine
2003;19(1):8-9
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the relationship between expression of C-FOS protein and brain concussion and find a sensitive marker of diagnosis of the brain concussion.
METHODS:Fifty-five rats were randomly divided into brain concussion groups and control group. The expression of C-FOS protein was microscopically observed by immunohistochemical method.
RESULTS:There were negative expression of C-FOS protein in control group. In brain concussion group, however, positive expression of C-FOS protein in some neurons was seen at 15 min after brain concussion, and reach to the peak at 6 h after brain concussion, then decreased gradually.
CONCLUSION:These findings suggest that detection of C-FOS protein could be an index of diagnosis of brain concussion and a sensitive marker of timing of injury after brain concussion.
