GDNF expression following the severe brain injury in rats.
- Author:
Xin WANG
1
;
Zhi-gang LIAO
;
Min LIU
Author Information
1. Forensic Pathology Department, School of Legal Medicine, Sichuan University, Chengdu 610041. xinwang974@sohu.com
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Animals;
Biomarkers;
Brain/metabolism*;
Brain Injuries/metabolism*;
Female;
Forensic Medicine;
Glial Cell Line-Derived Neurotrophic Factor;
Image Processing, Computer-Assisted;
Male;
Nerve Growth Factors/genetics*;
Rats;
Rats, Sprague-Dawley;
Time Factors
- From:
Journal of Forensic Medicine
2003;19(1):1-3
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the changes of GDNF after severe brain injury.
METHODS:Changes GDNF in cortex, thalamus and pontine was observed by using immunohistochemistry and image analysis technique.
RESULTS:The lever of GDNF was increasing at 1 d, reaching peak at 3 d, not obviously decreasing at 5 d and still higher than normal at 7 d after severe brain injury.
CONCLUSION:As an objective indication, the time sequence regularity of GDNF after brain injury may be applied in brain injury time estimation.
