Tryptase and fatal anaphylaxic reaction.
- Author:
Yi-wen SHEN
1
;
Chao LU
;
Zi-qin ZHAO
Author Information
1. Department of Forensic Medicine, Shanghai Medical School, Fudan University, Shanghai 200032. shenyiwen88@citiz.net
- Publication Type:Journal Article
- MeSH:
Adult;
Anaphylaxis/enzymology*;
Biomarkers/blood*;
Cause of Death;
Enzyme-Linked Immunosorbent Assay;
Female;
Forensic Medicine;
Humans;
Male;
Mast Cells/enzymology*;
Postmortem Changes;
Retrospective Studies;
Serine Endopeptidases/blood*;
Tryptases
- From:
Journal of Forensic Medicine
2002;18(3):132-136
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between tryptase in serum and anaphylaxis.
METHODS:The concentrations of tryptase in the sera of heart blood in three persons died from anaphylaxis shock were detected by ELISA. The first sample was obtained from a man, aged 38, died of injecting Amikacin. The second sample was obtained from a man, aged 42, died of injecting Cephradine. The third sample was from a woman, aged 39, died of injecting Lincomycin. All samples were stored in -20 degrees C.
RESULTS:The concentrations of tryptase in sera were 52 ng/ml, 121 ng/ml and 0.73 ng/ml. It was unknown why the concentration of tryptase in the third sample was normal.
CONCLUSION:In fetal anaphylaxia reaction tryptase measurement is a useful indicator, but the diagnosis is not to be based on the test alone.
