Cell apoptosis in closed cerebellar contusion in rat.
- Author:
Xing-biao LI
1
;
Yun HU
;
Kang XIA
Author Information
1. Department of Pathology, Wenzhou Medical College, Wenzhou, Zhejiang 325027.
- Publication Type:Journal Article
- MeSH:
Animals;
Apoptosis/physiology*;
Brain Injuries/pathology*;
Cerebellum/pathology*;
Female;
In Situ Nick-End Labeling;
Male;
Rats;
Rats, Sprague-Dawley;
Time Factors
- From:
Journal of Forensic Medicine
2002;18(2):74-77
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the cell apoptosis explore closed cerebellar contusion in rat.
METHODS:SD rats model of contusion was established and apototic cells were detected by TUNEL method at 5, 10, 30, 45, 60 min and 2, 4, 6, 8, 12 h, after injury.
RESULTS:Apototic cells in contusion area appeared at 1 h after closed cerebellar contusion, reached the peak at 4-6 h, then decreased and so as marginal area where the peak was in 6-8 h.
CONCLUSION:The apoptotic index of closed contusion of cerebellum in different injury time may provide a new sensitive and objective method for the forensic early injury time estimation.
