A quantitative analysis of peptidergic innervation in sinoatrial node in cases of sudden manhood death syndrome.
- Author:
Jian-ding CHENG
1
;
Yu-chuan CHEN
;
Bing-jie HU
Author Information
1. Department of Forensic Pathology, Sun Yat-sen University of Medical Sciences, Guangzhou 510080.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Adult;
Autonomic Nervous System/physiology*;
Death, Sudden/pathology*;
Humans;
Immunohistochemistry;
Male;
Myocardium/metabolism*;
Neuropeptide Y/metabolism*;
Sinoatrial Node/innervation*;
Vasoactive Intestinal Peptide/metabolism*
- From:
Journal of Forensic Medicine
2002;18(2):70-73
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the distribution and proportion of neuropeptide containing nervers in the sinus node in cases of sudden manhood death syndrome (SMDS) and to explore the mechanism of SMDS.
METHODS:Immunohistochemical staining and quantitative analysis of neuropeptide Y (NPY) and vasoactive intestinal peptide(VIP) in the sinus node in 6 cases of SMDS and in 12 cases of non-cardiac death(control group) were achieved by LSAB method and computerized image system.
RESULTS:As for NPY positive materials, VIP positive materials and the ratio of VIP/NPY in the sinus nodes, there were no significant difference between the control group and SMDS group.
CONCLUSION:The mechanism of SMDS and the abnormality of autonomic nervous innervation in the sinoatrial nodes maybe incorrelation.
