Screening of benzodizepines and their metabolites in urine.
- Author:
Bao-hua SHEN
1
;
Min SHEN
;
Xian-yi ZHUO
Author Information
1. Institute of Forensic Sciences, Ministry of Justice, Shanghai 200063.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Anti-Anxiety Agents/urine*;
Benzodiazepines/urine*;
Benzophenones/urine*;
Chromatography, Gas;
Gas Chromatography-Mass Spectrometry;
Humans
- From:
Journal of Forensic Medicine
2002;18(1):22-25
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:Screen seventeen benzodizepines and their metabolitesin urine by GC/ECD and GC/MS.
METHODS:They were GC (GC/ECD, GC/MS) assay of benzodizepines and GC (GC/ECD, GC/MS) assay of benzophenones of acid-hydrolytic products of 1,4-benzodizepines.
RESULTS:The methods were simple and sensitive. The recoverys were 60% to 90% of most benzodizepines, linear calibration curves were 20 ng/ml-200 ng/ml (r > 0.99), and detection limits were 0.5 ng/ml-10 ng/ml.
CONCLUSION:They methods were evaluated with human urine samples.
