An immunohistochemical study on the distribution in organs in cases with morphine poisoning.
- Author:
Ya-ming SHAN
1
;
Chun-yu HAO
;
Long WANG
Author Information
1. Shenyang Criminal Science and Technology Institute, Shenyang 110002.
- Publication Type:Journal Article
- MeSH:
Adult;
Brain/metabolism*;
Female;
Forensic Medicine;
Humans;
Immunohistochemistry;
Kidney/metabolism*;
Male;
Morphine/poisoning*;
Morphine Dependence/metabolism*;
Tissue Distribution
- From:
Journal of Forensic Medicine
2002;18(1):9-11
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the distribution of mophine in organs in cases with morphine poisioning to select ideal organs for immunohistochemical derection.
METHODS:Localization and half quantitation of morphine in the brain, the kidney, the heart, and the liver were studied in 8 cases with morphine poisoning by immunohistochemical SP method.
RESULTS:Morphine was mainly detected in the cytoplasm of certain parenchymal cells of the organs. The distribution varied greatly with different cases and organs. In the brain and kidney, morphine-positive cells could be easily found.
CONCLUSION:The kidney and brain may be the ideal organs for sampling in suspected morphine poisoning cases with.
