The expression of FN-IIIcs in the wound healing and its relationship with injury time.
- Author:
Yan JI
1
;
Zi-qin ZHAO
;
Yun-ju GU
Author Information
1. Department of Forensic Medicine of Fudan University, Shanghai 200032.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Animals;
Fibronectins/genetics*;
Forensic Medicine;
Humans;
Male;
RNA, Messenger/biosynthesis*;
Rats;
Rats, Sprague-Dawley;
Skin/metabolism*;
Time Factors;
Wound Healing/physiology*
- From:
Journal of Forensic Medicine
2002;18(1):4-6
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To research the expression of alternative splicing segment of fibronectin-IIIcs in incised wound of skin, to offer the experimental data for early injury time judgement.
METHODS:Using in situ hybridization with DIG-labeled anti-sense RNA probe, the expression of FN-IIIcs domain was detected in both human and rat skin incised wound.
RESULTS:(1) The expression of FN-IIIcs improved from the time of 30 min after injury, reached peak at 6 h and then reduced gradually. (2) The positive expression cells were mainly distributed in hair follicles, sebaceous glands and endothelium, however, in human beings they were basement cells of epidermis.
CONCLUSION:The expression of FN-IIIcs domain would be a supposed useful criteria for early injury time judgement.
