Berberine improves central memory formation of CD8+ T cells: Implications for design of natural product-based vaccines.
10.1016/j.apsb.2023.02.017
- Author:
Mingyan LI
1
;
Yaling WANG
1
;
Lingzhi ZHANG
1
;
Changxing GAO
1
;
Jing J LI
1
;
Jiandong JIANG
1
;
Qing ZHU
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
AMPK;
Berberine;
CD8+ T cell;
Central memory;
Naturally occurring compound;
Stat5;
T cell priming;
Vaccine design
- From:
Acta Pharmaceutica Sinica B
2023;13(5):2259-2268
- CountryChina
- Language:English
-
Abstract:
Berberine (BBR) as one of the most effective natural products has been increasingly used to treat various chronic diseases due to its immunosuppressive/tolerogenic activities. However, it is unknown if BBR can be applied without abrogating the efforts of vaccination. Here we show that priming of CD8+ T cells in the presence of BBR lead to improved central memory formation (Tcm) with substantially reduced effector proliferation, primarily orchestrated through activation of AMPK and Stat5. Tcm derived from vaccinated mice fed with BBR were able to adoptively transfer protective immunity to naïve recipients. Vaccination of BBR-fed mice conferred better memory protection against infection without losing immediate effector efficacy, suggesting appreciable benefits from using BBR in vaccination. Thus, our study may help to lay the groundwork for mechanistic understanding of the immunomodulatory effects of natural products and their potential use as adjuvant that allows the design of novel vaccines with more desirable properties.
