A multi-center observation of the therapeutic efficacy of Bencycloquidium bromide in the treatment of seasonal allergic rhinitis with predominant symptoms of rhinorrhea.

Weini HU; Tianhong Zhang; Yinghong Zhang; Chao Meng; Lifeng Xie; Yu Song; Chen DU; Chiyu XU; Yali DU; Qiang Zuo; Fengyang AN; Yuhui Wang; Cuida Meng; Lei Zhang; Dongdong Zhu; Li Zhu

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A multi-center observation of the therapeutic efficacy of Bencycloquidium bromide in the treatment of seasonal allergic rhinitis with predominant symptoms of rhinorrhea.

Author: Weini HU ¹ ; Tianhong ZHANG ² ; Yinghong ZHANG ¹ ; Chao MENG ¹ ; Lifeng XIE ¹ ; Yu SONG ¹ ; Chen DU ¹ ; Chiyu XU ¹ ; Yali DU ¹ ; Qiang ZUO ¹ ; Fengyang AN ¹ ; Yuhui WANG ¹ ; Cuida MENG ³ ; Lei ZHANG ² ; Dongdong ZHU ³ ; Li ZHU ¹
Author Information

1. Department of Otolaryngology Head and Neck Surgery，Peking University Third Hospital，Beijing，100191，China.
2. Department of Otolaryngology Head and Neck Surgery，the First Affiliated Hospital of Harbin Medical University.
3. Department of Otolaryngology Head and Neck Surgery，China-Japanese Friendship Hospital，Jilin University.
Publication Type:Journal Article
Keywords: allergic rhinitis; cholinergic antagonists; nasal sprays
MeSH: Male; Female; Humans; Adult; Rhinitis, Allergic, Seasonal/drug therapy*; Nasal Sprays; Quality of Life; Administration, Intranasal; Rhinorrhea; Double-Blind Method; Treatment Outcome; Rhinitis, Allergic/drug therapy*
From: Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2023;37(7):550-555
CountryChina
Language:Chinese
Abstract: Objective:To observe the efficacy and safety of the M receptor antagonist Bencycloquidium bromide nasal spray in treatment of seasonal allergic rhinitis with runny nose as the main symptom. Methods:From August 2021 to September 2021, 134 patients with seasonal allergic rhinitis were enrolled in the otolaryngology Outpatient Department of Peking University Third Hospital, First Affiliated Hospital of Harbin Medical University and China-Japanese Friendship Hospital of Jilin University, including 71 males and 63 females, with a median age of 38 years. TNSS score and visual analogue scale（VAS） of total nasal symptoms were observed during 2 weeks of treatment with Bencycloquidium bromide nasal spray. Results:TNSS score decreased from （8.89±3.31） on day 0 to （3.71±2.51） on day 14（P<0.001）, VAS score of nasal symptoms decreased from （24.86±7.40） on day 0 to （6.84±5.94） on day 14（P<0.001）, VAS score of rhinorrhoea decreased from （6.88±2.06） on day 0 to （1.91±1.81） on day 14（P<0.001）. Rhinoconjunctivitis quality of life questionnaire（RQLQ） score decreased from （94.63±33.35） on day 0 to （44.95±32.28） on day 14（P<0.001）. The incidence of adverse reaction was low and no serious adverse events occurred during the whole experiment. Conclusion:Bencycloquidium bromide nasal spray has significant efficacy and good safety in the treatment of seasonal allergic rhinitis.