Value of allergen nasal provocation test in assessment of the efficacy of house dust mites specific immunotherapy.
10.13201/j.issn.2096-7993.2023.06.005
- Author:
Duohui LI
1
;
Hao XIAO
1
;
Shixi LIU
1
;
Qiaoru JIA
1
;
Li ZHANG
1
;
Chuqi SHI
1
;
Juan MENG
1
Author Information
1. Department of Otolaryngology，Head and Neck Surgery，West China Hospital，Sichuan University Allergen Center of West China Hospital，Sichuan University，Chengdu，610041，China.
- Publication Type:Journal Article
- Keywords:
allergen immunotherapy;
allergic rhinitis;
combined symptom and medication score;
dust mite;
nasal provocation test
- MeSH:
Animals;
Humans;
Pyroglyphidae;
Allergens;
Nasal Provocation Tests;
Quality of Life;
Rhinitis, Allergic/therapy*;
Desensitization, Immunologic;
Skin Tests;
Dust
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2023;37(6):428-441
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of nasal provocation test（NPT） in evaluating the efficacy of allergen immunotherapy（AIT） in patients with dust mite induced allergic rhinitis（AR）. Methods:A total of 83 patients with dust mite induced AR with/without asthma were included. Symptom score（SS）, daily medication score（DMS）, combined symptom and medication score（CSMS）, rhinoconjunctivitis quality of life questionnaire（RQLQ）, NPT and skin prick test（SPT） were assessed before and after 1 year AIT. Results:There were statistical differences in SS（P<0.000 1）, DMS（P<0.000 1）, CSMS（P<0.000 1）, and RQLQ（P<0.000 1） after 1 year of AIT compared with pre-treatment. The effective rate of CSMS was 73.49%, and the effective rate of NPT was 42.17%. CSMS was consistent with NPT in efficacy assessment（Kappa=0.437, P<0.001）; while in 54 patients with pre-treatment NPT concentrations other than the original concentration, CMSM and NPT showed better consistence（Kappa=0.895, P<0.001）. Among the 48 patients with ineffective NPT assessment in the first year, 25 patients completed the second-year follow-up, and 12 patients（48.00%） showed effective in NPT. However, 10 out of 12 patients（83.33%） with NPT concentration other than original solution pre-treatment showed effective NPT at the second year. Conclusion:NPT can be used as one of the indicators for efficacy evaluation for dust mite induced AR patients, especially for patients with positive NPT induced at lower concentrations before treatment.
