Risk factors of recurrence and canceration for premalignant vocal fold lesions after surgery.
10.13201/j.issn.2096-7993.2023.05.007
- Author:
Hailan MO
1
;
Hongyan FANG
1
;
Rui LUO
1
;
Xiufu LIAO
1
;
Leilei GAO
1
;
Mei SONG
1
;
Xia ZHOU
1
;
Wei YUAN
1
Author Information
1. Department of Otolaryngology，Chongqing General Hospital，Chongqing，400014，China.
- Publication Type:Journal Article
- Keywords:
malignant transformation;
precancerous lesions of vocal cords;
recurrence;
risk factors
- MeSH:
Humans;
Vocal Cords/pathology*;
Retrospective Studies;
Laryngopharyngeal Reflux/complications*;
Prospective Studies;
Precancerous Conditions/pathology*;
Risk Factors
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2023;37(5):354-359
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the risk factors of recurrence and canceration for premalignant vocal fold lesions after surgery, and to provide a reasonable basis for preoperative evaluation and postoperative follow-up. Methods:This study retrospective analyzed the relationship between clinicopathological factors and clinical outcome（recurrence, canceration, recurrence-free survival, and canceration-free survival） in 148 patients undergoing surgical treatment in Chongqing General Hospital from 2014 to 2017. Results:The five-year overall recurrence rate was 14.86% and the overall recurrence rate was 8.78%. Univariate analysis showed that smoking index, laryngopharyngeal reflux and lesion range were significantly associated with recurrence（P<0.05）, and smoking index and lesion range were significantly associated with canceration（P<0.05）. Multivariate logistic regression analysis showed that smoking index ≥600 and laryngopharyngeal reflux were independent risk factors for recurrence（P<0.05）, and smoking index ≥600 and lesion range ≥1/2 vocal cord were independent risk factors for canceration（P<0.05）. The mean carcinogenesis interval for the postoperative smoking cessation group was significantly longer（P<0.05）. Conclusion:Excessive smoking, laryngopharyngeal reflux and a wide range of lesions may be related to postoperative recurrence or malignant progression of precancerous lesions in the vocal cord, and further large-scale multi-center prospective randomized controlled studies are needed to clarify the effects of the above factors on recurrence and malignant changes in the future.
