The outcome of transnasal endoscopic total maxillectomy in the treatment of sinonasal adenoid cystic carcinoma.
10.13201/j.issn.2096-7993.2023.04.001
- Author:
Quan LIU
1
;
Yuting LAI
1
;
Jingyi YANG
1
;
Huankang ZHANG
1
;
Xicai SUN
1
;
Yurong GU
1
;
Houyong LI
1
;
Hongmeng YU
1
;
Dehui WANG
1
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery，Eye and ENT Hospital，Fudan University，Shanghai，200031，China.
- Publication Type:Journal Article
- Keywords:
adenoid cystic carcinoma;
endoscopic surgical procedures;
maxillary sinus neoplasms;
prognosis;
total maxillectomy
- MeSH:
Humans;
Carcinoma, Adenoid Cystic/pathology*;
Paranasal Sinus Neoplasms/pathology*;
Retrospective Studies;
Neoplasm Recurrence, Local/pathology*;
Prognosis
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2023;37(4):243-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the prognosis of sinonasal adenoid cystic carcinoma with hard palatine invasion treated by transnasal endoscopic total maxillectomy. Methods:Clinical data of twenty-six patients with sinonasal adenoid cystic carcinoma invading hard palatine treated by transnasal endoscopic total maxillectomy between May 2014 and December 2020 was analyzed retrospectively. Survival rate, local recurrence and distant metastasis were analyzed using Kaplan-Meier method. Cox regression was used to investigate the prognosis factors. Masticatory function after maxillectomy has also been assessed using the questionnaire of patients' satisfaction about masticatory function. Results:Margins in 8 patients（30%） were positive. The median time of follow-up was 38 months（6 to 85 months）. Twenty-five patients recurred. Four patients died of distant metastasis. The 5-year overall survival rate and relapse-free survival rate was 79.5% and 89.1%, respectively. Independent predictors of outcome on multivariate analysis were positive margin（P=0.018）, recurrence（P=0.006） and distant metastasis（P=0.04）. Conclusion:Transnasal endoscopic total maxillectomy could be performed for the treatment of the sinonasal adenoid cystic carcinoma with hard palatine invasion. Positive margin, local recurrence and distant metastasis were important predictors for patients' prognosis.
