New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus.
10.1016/S1875-5364(23)60446-7
- Author:
Xinxin CAO
1
;
Xinxin WANG
1
;
Yu ZHANG
1
;
Defeng XU
1
;
Xiuqing SONG
1
;
Jinhai YU
1
;
Jie BAO
1
;
Junsheng ZHANG
2
;
Hua ZHANG
3
Author Information
1. School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
2. School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: bio_zhangjs@ujn.edu.cn.
3. School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: bio_zhangh@ujn.edu.cn.
- Publication Type:Journal Article
- Keywords:
Diterpenoid;
Labdane;
Leonurus japonicus;
Neuroprotective activity
- MeSH:
Magnetic Resonance Spectroscopy;
Leonurus/chemistry*;
Plants, Medicinal;
Diterpenes/chemistry*;
Plant Components, Aerial;
Molecular Structure
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(7):551-560
- CountryChina
- Language:English
-
Abstract:
Phytochemical investigation on the ethanol extract of a well-known medicinal herb Leonurus japonicus, led to the separation of 18 labdane type diterpenoids (1-18). Through comprehensive spectroscopic analyses and quantum chemical calculations, these compounds were structurally characterized as six new interesting 5,5,5-di-spirocyclic ones (1-6), two new (7 and 8) and six known (13-18) interesting 6,5,5-di-spirocyclic ones, a new rare 14,15-dinor derivative (9), and three new ones incorporating a γ-lactone unit (10-12). An in vitro neuroprotective assay in RSC96 cells revealed that compounds 7 and 12 exhibited neuroprotective activity in a concentration-dependent way, comparable to the reference drug N-acetylcysteine.
