A comprehensive review of natural products with anti-hypoxic activity.
10.1016/S1875-5364(23)60410-8
- Author:
Juncai LIU
1
;
Zhen GE
1
;
Xiao JIANG
2
;
Jingjing ZHANG
2
;
Jianan SUN
3
;
Xiangzhao MAO
4
,
5
Author Information
1. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
2. Medical College, Qingdao Binhai University, Qingdao 266555, China.
3. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China. Electronic address: sunjianan@ouc.edu.cn.
4. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China
5. Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China. Electronic address: zhmao@ouc.edu.cn.
- Publication Type:Review
- Keywords:
Activity;
Anti-hypoxia;
Mechanism;
Natural products
- MeSH:
Humans;
Biological Products/therapeutic use*;
Hypoxia/metabolism*;
Reactive Oxygen Species/metabolism*;
Adenosine Triphosphate/metabolism*;
Alkaloids
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(7):499-515
- CountryChina
- Language:English
-
Abstract:
Natural products exhibit substantial impacts in the field of anti-hypoxic traetment. Hypoxia can cause altitude sickness and other negative effect on the body. Headache, coma, exhaustion, vomiting and, in severe cases, death are some of the clinical signs. Currently, hypoxia is no longer just a concern in plateau regions; it is also one of the issues that can not be ignored by urban residents. This review covered polysaccharides, alkaloids, saponins, flavonoids, peptides and traditional Chinese compound prescriptions as natural products to protect against hypoxia. The active ingredients, effectiveness and mechanisms were discussed. The related anti-hypoxic mechanisms involve increasing the hemoglobin (HB) content, glycogen content and adenosine triphosphate (ATP) content, removing excessive reactive oxygen species (ROS), reducing lipid peroxidation, regulating the levels of related enzymes in cells, protecting the structural and functional integrity of the mitochondria and regulating the expression of apoptosis-related genes. These comprehensive summaries are beneficial to anti-hypoxic research and provide useful information for the development of anti-hypoxic products.
