Herbal medicines for insomnia through regulating 5-hydroxytryptamine receptors: a systematic review.
10.1016/S1875-5364(23)60405-4
- Author:
Haoran WANG
1
,
2
;
Yanqiu GU
3
;
Rahman KHALID
4
;
Xiaofei CHEN
5
;
Ting HAN
6
Author Information
1. School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China
2. School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
3. Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 201999, China.
4. Faculty of Science, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, England.
5. School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China. Electronic address: xfchen2010@163.com.
6. School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China. Electronic address: hanting@smmu.edu.cn.
- Publication Type:Review
- Keywords:
5-HT receptors;
5-Hydroxytryptamine;
Herbal medicine;
Insomnia
- MeSH:
Humans;
Sleep Initiation and Maintenance Disorders/drug therapy*;
Medicine, Chinese Traditional;
Drugs, Chinese Herbal/therapeutic use*;
Plants, Medicinal;
Receptors, Serotonin;
Serotonin
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(7):483-498
- CountryChina
- Language:English
-
Abstract:
Insomnia is a common sleep disorder without effective therapy and can affect a person's life. The mechanism of the disease is not completely understood. Hence, there is a need to understand the targets related to insomnia, in order to develop innovative therapies and new compounds. Recently, increasing interest has been focused on complementary and alternative medicines for treating or preventing insomnia. Research into their molecular components has revealed that their sedative and sleep-promoting properties rely on the interactions with various neurotransmitter systems in the brain. In this review, the role of 5-hydroxytryptamine (5-HT) in insomnia development is summarized, while a systematic analysis of studies is conducted to assess the mechanisms of herbal medicines on different 5-HT receptors subtypes, in order to provide reference for subsequent research.
