Geranylated or prenylated flavonoids from Cajanus volubilis.
10.1016/S1875-5364(23)60437-6
- Author:
Li RAO
1
;
Yu SU
1
;
Qian HE
1
;
Jia YE
1
;
Yu LIU
1
;
Yue FAN
1
;
Feng HU
1
;
Zhen ZHOU
1
;
Lishe GAN
2
;
Yonghui ZHANG
3
;
Chuanrui ZHANG
4
,
5
Author Information
1. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China.
2. School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020, China.
3. Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area, Chongqing Three Gorges Medical College, Chongqing 404120, China. Electronic address: zhangyonghui@cqtgmc.edu.cn.
4. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China
5. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: crzhang@cqu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Cajanus volubilis;
Cytotoxicity;
Geranylated chalcone;
Prenylated flavone;
Prenylated isoflavanone
- MeSH:
Flavonoids/chemistry*;
Cajanus;
Molecular Structure;
Chalcones/chemistry*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(4):292-297
- CountryChina
- Language:English
-
Abstract:
Five new flavonoid derivatives, cajavolubones A-E (1-5), along with six known analogues (6-11) were isolated from Cajanus volubilis, and their structures were elucidated by spectroscopic analysis and quantum chemical calculations. Cajavolubones A and B (1 and 2) were identified as two geranylated chalcones. Cajavolubone C (3) was a prenylated flavone, while cajavolubones D and E (4 and 5) were two prenylated isoflavanones. Compounds 3, 8, 9 and 11 displayed cytotoxicity against HCT-116 cancer cell line.
