A new target of precision medicine in sepsis: gut microbiome modified tryptophan metabolism.
10.3760/cma.j.cn121430-20221008-00884
- Author:
Xinlei HE
1
;
Xiao CUI
;
Yuxin LENG
Author Information
1. Department of Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China. Corresponding author: Leng Yuxin, Email: lengyx@bjmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Humans;
Gastrointestinal Microbiome/physiology*;
Tryptophan/metabolism*;
Precision Medicine;
Sepsis
- From:
Chinese Critical Care Medicine
2023;35(7):764-768
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by dysregulated host responses to infection. Despite significant advances in anti-infective, immunomodulatory, and organ function support technologies, the precise and targeted management of sepsis remains a challenge due to its high heterogeneity. Studies have identified disturbed tryptophan (TRP) metabolism as a common mechanism in multiple diseases, which is involved in both immune regulation and the development of multi-organ damages. The rise of research on intestinal microflora has further highlighted the critical role of microflora-regulated TRP metabolism in pathogen-host interactions and the "cross-talk" among multi-organs, making it a potential key target for precision medicine in sepsis. This article reviews TRP metabolism, the regulation of TRP metabolism by the intestinal microflora, and the characteristics of TRP metabolism in sepsis, providing clues for further clinical targeting of TRP metabolism for precision medicine in sepsis.
