Research of progress of mitochondria in the pathogenesis of sepsis.
10.3760/cma.j.cn121430-20220809-00735
- Author:
Liwei YU
1
;
Zhiling ZHAO
;
Gaiqi YAO
Author Information
1. Department of Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China. Corresponding author: Yao Gaiqi, Email: yaogaiqi@sina.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Mitochondria/pathology*;
Sepsis/drug therapy*;
Oxidative Stress;
Autophagy
- From:
Chinese Critical Care Medicine
2023;35(6):669-672
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is an organ dysfunction caused by dysregulation of the body's response to infection, with high morbidity and mortality. The pathogenesis of sepsis is still unclear, and there are no specific treatment drugs. As a cell energy supply unit, the dynamic changes of mitochondria are closely related to various diseases. Studies have shown that structure and function of mitochondria are changed in different organs during sepsis. The energy shortage, oxidative stress change, imbalance of fusion and fission, autophagy reduce, biological functions of mitochondria play important roles in sepsis progress, which can provide a research target for the treatment of sepsis.
