Research progress of mtDNA in acute respiratory distress syndrome.
10.3760/cma.j.cn121430-20220629-00614
- Author:
Jing HAN
1
;
Xiaoyue LI
2
;
Jie ZHANG
2
Author Information
1. Zhuhai Campus of Zunyi Medical University, Zhuhai 519000, Guangdong, China.
2. Department of Critical Care Medicine, the Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai), Zhuhai 519000, Guangdong, China. Corresponding author: Li Xiaoyue, Email: euyeuy1983@126.com.
- Publication Type:Journal Article
- MeSH:
Humans;
DNA, Mitochondrial;
Mitochondria;
Inflammation;
Permeability;
Respiratory Distress Syndrome
- From:
Chinese Critical Care Medicine
2023;35(5):558-560
- CountryChina
- Language:Chinese
-
Abstract:
Acute respiratory distress syndrome (ARDS) is a common cause of death in critically ill patients. At present, the pathogenesis of ARDS has not been clarified, which is mainly related to excessive inflammatory response, increased endothelial and epithelial permeability, and decreased alveolar surfactant. In recent years, many studies have shown that mitochondrial DNA (mtDNA) is involved in the occurrence and development of ARDS by inducing inflammation and activating immune response, and has the potential to be used as biomarkers for ARDS. This article reviews the role of mtDNA in the pathogenesis of ARDS, aiming to provide new strategies for the treatment of ARDS, and ultimately reduce the mortality of ARDS patients.
