Traditional Chinese therapy in the treatment of ICU-acquired weakness: a Meta-analysis.
10.3760/cma.j.cn121430-20220301-00191
- Author:
Xinbei ZHOU
1
;
Yaoying JIN
1
;
Liang LIU
1
;
Jun DUAN
2
Author Information
1. Graduate School of Beijing University of Chinese Medicine, Beijing 100029, China.
2. Department of Intensive Care Unit, Beijing China-Japan Friendship Hospital, Beijing 100029, China. Corresponding author: Duan Jun, Email: 13691362130@163.com.
- Publication Type:Journal Article
- MeSH:
Humans;
APACHE;
East Asian People;
Intensive Care Units;
Interleukin-6;
Tumor Necrosis Factor-alpha;
Medicine, Chinese Traditional;
Muscle Weakness/therapy*
- From:
Chinese Critical Care Medicine
2023;35(5):538-544
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically assess the efficacy of traditional Chinese therapy in the treatment of ICU-acquired weakness (ICU-AW).
METHODS:PubMed, Cochrane Library, Embase, Web of Science, CNKI, Wanfang, VIP were retrieved by computer and were used to collect a randomized controlled trials (RCT) of traditional Chinese therapy for ICU-AW. The retrieval time was from databases establishment to December 2021. After 2 researchers independently screened the literature, extracted data and evaluated the risk of bias included in the study, and RevMan 5.4 software was used for Meta-analysis.
RESULTS:334 articles were selected, totally 13 clinical studies and 982 patients were included, including 562 in the trial group and 420 in the control group. Meta-analysis results showed that traditional Chinese therapy could improve clinical efficacy of ICU-AW patients [relative risk (RR) = 1.35, 95% confidence interval (95%CI) was 1.20 to 1.52, P < 0.000 01], improve the muscle strength [Medical Research Council score (MRC score); standardized mean difference (SMD) = 1.00, 95%CI was 0.67 to 1.33, P < 0.000 01], improve daily life ability [modified Barthel index score (MBI score); SMD = 1.67, 95%CI was 1.20 to 2.14, P < 0.000 01], shorten mechanical ventilation time (SMD = -1.47, 95%CI was -1.84 to -1.09, P < 0.000 01), reduce the length of intensive care unit (ICU) stay [mean difference (MD) = -3.28, 95%CI was -3.89 to -2.68, P < 0.000 01], reduce the total hospitalization time (MD = -4.71, 95%CI was -5.90 to -3.53, P < 0.000 01), reduce tumor necrosis factor-α (TNF-α; MD = -4.55, 95%CI was -6.39 to -2.70, P < 0.000 01) and interleukin-6 (IL-6; MD = -5.07, 95%CI was -6.36 to -3.77, P < 0.000 01). There was no obvious advantage in reducing the severity of the disease [acute physiology and chronic health evaluation II (APACHE II; SMD = -0.45, 95%CI was -0.92 to 0.03, P = 0.07).
CONCLUSIONS:Based on the current research, traditional Chinese therapy can improve the clinical efficacy of ICU-AW, improve muscle strength and daily life ability, shorten mechanical ventilation, the length of ICU stay and total hospitalization time, reduce TNF-α and IL-6. But traditional Chinese therapy can not reduce the overall disease severity.
