Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex.
10.1007/s12264-023-01038-5
- Author:
Ankang HU
1
;
Rui ZHAO
1
;
Baihui REN
2
;
Yang LI
3
;
Jiangteng LU
4
;
Yilin TAI
5
Author Information
1. The State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
2. Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
3. The State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, Shanghai, 200032, China. liyang_@fudan.edu.cn.
4. Center for Brain Science of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. jiangtenglu@shsmu.edu.cn.
5. The State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, Shanghai, 200032, China. taiyilin@fudan.edu.cn.
- Publication Type:Journal Article
- Keywords:
Axon initial segment;
Chandelier cell;
Heterogeneity;
Pyramidal neurons
- MeSH:
Mice;
Animals;
Axon Initial Segment;
Synapses/physiology*;
Pyramidal Cells/physiology*;
Cerebral Cortex;
Axons/physiology*
- From:
Neuroscience Bulletin
2023;39(7):1050-1068
- CountryChina
- Language:English
-
Abstract:
The axon initial segment (AIS) is a highly specialized axonal compartment where the action potential is initiated. The heterogeneity of AISs has been suggested to occur between interneurons and pyramidal neurons (PyNs), which likely contributes to their unique spiking properties. However, whether the various characteristics of AISs can be linked to specific PyN subtypes remains unknown. Here, we report that in the prelimbic cortex (PL) of the mouse, two types of PyNs with axon projections either to the contralateral PL or to the ipsilateral basal lateral amygdala, possess distinct AIS properties reflected by morphology, ion channel expression, action potential initiation, and axo-axonic synaptic inputs from chandelier cells. Furthermore, projection-specific AIS diversity is more prominent in the superficial layer than in the deep layer. Thus, our study reveals the cortical layer- and axon projection-specific heterogeneity of PyN AISs, which may endow the spiking of various PyN types with exquisite modulation.
