Chromatin Remodeling Factor SMARCA5 is Essential for Hippocampal Memory Maintenance via Metabolic Pathways in Mice.
10.1007/s12264-023-01032-x
- Author:
Yu QU
1
;
Nan ZHOU
2
;
Xia ZHANG
1
;
Yan LI
3
;
Xu-Feng XU
4
Author Information
1. Institute of Neuropsychiatric Diseases, Qingdao University, Qingdao, 266001, China.
2. Department of Urology, Qilu Hospital of Shandong University, Jinan, 250012, China.
3. Department of Urology, Qilu Hospital of Shandong University, Jinan, 250012, China. yanli@sdu.edu.cn.
4. Institute of Neuropsychiatric Diseases, Qingdao University, Qingdao, 266001, China. Xuxufeng@qdu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Chromatin remodeling;
Epigenetic regulation;
Hippocampal memory;
Metabolic pathway;
SMARCA5
- MeSH:
Mice;
Animals;
Memory;
Chromatin Assembly and Disassembly;
Hippocampus/metabolism*;
Transcription Factors/metabolism*;
Chromatin/metabolism*;
Metabolic Networks and Pathways
- From:
Neuroscience Bulletin
2023;39(7):1087-1104
- CountryChina
- Language:English
-
Abstract:
Gene transcription and new protein synthesis regulated by epigenetics play integral roles in the formation of new memories. However, as an important part of epigenetics, the function of chromatin remodeling in learning and memory has been less studied. Here, we showed that SMARCA5 (SWI/SNF related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 5), a critical chromatin remodeler, was responsible for hippocampus-dependent memory maintenance and neurogenesis. Using proteomics analysis, we found protein expression changes in the hippocampal dentate gyrus (DG) after the knockdown of SMARCA5 during contextual fear conditioning (CFC) memory maintenance in mice. Moreover, SMARCA5 was revealed to participate in CFC memory maintenance via modulating the proteins of metabolic pathways such as nucleoside diphosphate kinase-3 (NME3) and aminoacylase 1 (ACY1). This work is the first to describe the role of SMARCA5 in memory maintenance and to demonstrate the involvement of metabolic pathways regulated by SMARCA5 in learning and memory.
