Functional Autapses Form in Striatal Parvalbumin Interneurons but not Medium Spiny Projection Neurons.
10.1007/s12264-022-00991-x
- Author:
Xuan WANG
1
;
Zhenfeng SHU
2
;
Quansheng HE
2
;
Xiaowen ZHANG
2
;
Luozheng LI
1
;
Xiaoxue ZHANG
2
;
Liang LI
2
;
Yujie XIAO
2
;
Bo PENG
2
;
Feifan GUO
2
;
Da-Hui WANG
3
;
Yousheng SHU
4
Author Information
1. School of Systems Science and State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
2. Department of Neurosurgery, Jinshan Hospital, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institute for Translational Brain Research, Fudan University, Shanghai, 200032, China.
3. School of Systems Science and State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China. wangdh@bnu.edu.cn.
4. Department of Neurosurgery, Jinshan Hospital, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institute for Translational Brain Research, Fudan University, Shanghai, 200032, China. yousheng@fudan.edu.cn.
- Publication Type:Journal Article
- Keywords:
Asynchronous neurotransmitter release;
Autapse;
Parvalbumin interneuron;
Spiny projection neuron;
Striatum
- MeSH:
Parvalbumins/metabolism*;
Corpus Striatum/metabolism*;
Interneurons/physiology*;
Neurons/metabolism*;
Neostriatum
- From:
Neuroscience Bulletin
2023;39(4):576-588
- CountryChina
- Language:English
-
Abstract:
Autapses selectively form in specific cell types in many brain regions. Previous studies have also found putative autapses in principal spiny projection neurons (SPNs) in the striatum. However, it remains unclear whether these neurons indeed form physiologically functional autapses. We applied whole-cell recording in striatal slices and identified autaptic cells by the occurrence of prolonged asynchronous release (AR) of neurotransmitters after bursts of high-frequency action potentials (APs). Surprisingly, we found no autaptic AR in SPNs, even in the presence of Sr2+. However, robust autaptic AR was recorded in parvalbumin (PV)-expressing neurons. The autaptic responses were mediated by GABAA receptors and their strength was dependent on AP frequency and number. Further computer simulations suggest that autapses regulate spiking activity in PV cells by providing self-inhibition and thus shape network oscillations. Together, our results indicate that PV neurons, but not SPNs, form functional autapses, which may play important roles in striatal functions.
