Biomarkers of malignant transformation in oral leukoplakia: from bench to bedside.

Xinjia Cai; Jianyun Zhang; Heyu Zhang; Tiejun LI

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Biomarkers of malignant transformation in oral leukoplakia: from bench to bedside.

Author: Xinjia CAI ¹ ; Jianyun ZHANG ¹ ; Heyu ZHANG ² ; Tiejun LI ³
Author Information

1. Department of Oral Pathology, Peking University School and Hospital of Stomatology / National Center of Stomatology / National Clinical Research Center for Oral Diseases / National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
2. Central Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China. litiejun22@vip.sina.com.
3. Department of Oral Pathology, Peking University School and Hospital of Stomatology / National Center of Stomatology / National Clinical Research Center for Oral Diseases / National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China. zhangheyu1983@sina.cn.
Publication Type:Journal Article
Keywords: Biomarker; Malignant transformation; Oral leukoplakia; Oral squamous cell carcinoma; Prognosis
From: Journal of Zhejiang University. Science. B 2023;():1-15
CountryChina
Language:English
Abstract: Oral leukoplakia is a common precursor lesion of oral squamous cell carcinoma, which indicates a high potential of malignancy. The malignant transformation of oral leukoplakia seriously affects patient survival and quality of life; however, it is difficult to identify oral leukoplakia patients who will develop carcinoma because no biomarker exists to predict malignant transformation for effective clinical management. As a major problem in the field of head and neck pathologies, it is imperative to identify biomarkers of malignant transformation in oral leukoplakia. In this review, we discuss the potential biomarkers of malignant transformation reported in the literature and explore the translational probabilities from bench to bedside. Although no single biomarker has yet been applied in the clinical setting, profiling for genomic instability might be a promising adjunct.