Incidence and risk factors of early transient intraocular pressure elevation after canaloplasty for primary open-angle glaucoma.

Lijuan XU; Xinyao Zhang; Yang Cao; Yin Zhao; Juan GU; Wenqing YE; Xiaojie Wang; Jinxin LI; Ruiyi Ren; Yuanbo Liang

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Incidence and risk factors of early transient intraocular pressure elevation after canaloplasty for primary open-angle glaucoma.

Author: Lijuan XU ¹ ; Xinyao ZHANG ¹ ; Yang CAO ¹ ; Yin ZHAO ¹ ; Juan GU ² ; Wenqing YE ¹ ; Xiaojie WANG ¹ ; Jinxin LI ¹ ; Ruiyi REN ³ ; Yuanbo LIANG ⁴
Author Information

1. National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
2. Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu 610086, China.
3. National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China. yuanboliang@wmu.edu.cn, renruiyi@bu.edu.
4. National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China. yuanboliang@wmu.edu.cn.
Publication Type:Journal Article
MeSH: Humans; Intraocular Pressure; Glaucoma, Open-Angle/surgery*; Incidence; Treatment Outcome; Risk Factors
From: Journal of Zhejiang University. Science. B 2023;24(4):366-370
CountryChina
Language:English
Abstract: Glaucoma is one of the most common optic neuropathies, featuring progressive retinal ganglion cell damage and visual field loss (Tham et al., 2014; Xu et al., 2020). Currently, the only effective treatment for this condition is the reduction of intraocular pressure (IOP) (Palmberg, 2001; Heijl et al., 2002). Canaloplasty is a proven bleb-independent surgery with good efficacy and safety profiles in primary open-angle glaucoma (POAG) (Gołaszewska et al., 2021). However, early transient postoperative IOP elevation has been reported in up to 30% of cases (Riva et al., 2019), similar to that commonly observed in other internal drainage glaucoma surgeries such as implantation using iStent (0%-21.0%), CyPass (10.8%), and Hydrus (4.8%-6.5%) (Lavia et al., 2017). This complication may be a predictor of poor reserve in the outflow system and is potentially associated with surgical failure. Nonetheless, the exact pathophysiology of glaucoma remains unknown, and studies clarifying the risk factors for postoperative IOP elevation have been scarce.