Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction.
- Author:
Jingru LI
1
;
Haocheng MA
1
;
Xinyu WU
1
;
Guihu SUN
1
;
Ping YANG
1
;
Yunzhu PENG
1
;
Qixian WANG
1
;
Luqiao WANG
2
Author Information
- Publication Type:Journal Article
- Keywords: Circular RNA (circRNA); Exosomal ncRNA; Exosome; Long non-coding RNA (lncRNA); MicroRNA (miRNA); Myocardial Infarction (MI); Non-exosomal non-coding RNA (ncRNA)
- MeSH: Humans; RNA, Untranslated/genetics*; RNA; Myocardial Infarction/genetics*; Biomarkers; Computational Biology; MicroRNAs/genetics*
- From: Journal of Zhejiang University. Science. B 2023;24(4):281-300
- CountryChina
- Language:English
- Abstract: Non-exosomal non-coding RNAs (non-exo-ncRNAs) and exosomal ncRNAs (exo-ncRNAs) have been associated with the pathological development of myocardial infarction (MI). Accordingly, this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs. We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis. The following contributions are made: (1) we comprehensively describe the expression profile, competing endogenous RNA (ceRNA) network, and "pre-necrotic" biomarkers of non-exo/exo-ncRNAs for MI; (2) functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress, etc.; (3) we propose an updated and comprehensive view on the mechanisms, pathophysiology, and biomarker roles of non-exo/exo-ncRNAs in MI, thereby providing a theoretical basis for the clinical management of MI.
