Research progress in the cardiac lymphatic system and myocardial repair after myocardial infarction.
10.11817/j.issn.1672-7347.2023.220636
- Author:
Tingyu DENG
1
;
Zhaofeng SHI
2
;
Yichao XIAO
3
Author Information
1. Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha 410011. dty020204@163.com.
2. Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha 410011.
3. Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha 410011. yichaoxiao@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
lymphangiogenesis;
lymphatic system;
myocardial infarction
- MeSH:
Animals;
Heart;
Myocardium;
Myocardial Infarction;
Heart Injuries;
Lymphatic System
- From:
Journal of Central South University(Medical Sciences)
2023;48(6):920-929
- CountryChina
- Language:English
-
Abstract:
The lymphatic system of the heart plays an important role in the repair process after myocardial injury and may regulate normal tissue homeostasis and natural regeneration via maintaining fluid homeostasis and controlling the inflammatory response. The lymphatic system in the heart is activated after myocardial injury and is involved in the scarring process of the heart. Recent studies on the lymphatic system and myocardial repair of the heart have developed rapidly, and the mechanisms for lymphangiogenesis and lymphatic endothelial cell secretion have been elucidated by different animal models. A deep understanding of the structural, molecular, and functional characteristics of the lymphatic system of the heart can help develop therapies that target the lymphatic system in the heart. Summarizing the progress in studies on targets related to myocardial repair and the cardiac lymphatic system is helpful to provide potential new targets and strategies for myocardial repair therapy after myocardial infarction.
