Let -7i : A key player and a promising biomarker in diseases.
10.11817/j.issn.1672-7347.2023.220146
- Author:
Jiali HOU
1
;
Xuan SUN
2
Author Information
1. Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha 410078. 2224020908@qq.com.
2. Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha 410078. 610663156@qq.com.
- Publication Type:Journal Article
- Keywords:
biomarker;
cerebrovascular diseases;
fibrotic diseases;
immunomodulation;
let-7i;
tumor
- MeSH:
Biomarkers;
Apoptosis;
Autophagy;
Epigenesis, Genetic;
MicroRNAs/genetics*
- From:
Journal of Central South University(Medical Sciences)
2023;48(6):909-919
- CountryChina
- Language:English
-
Abstract:
MicroRNAs (miRNAs) are endogenous non-coding single-stranded small RNAs that regulate gene expression by recognizing homologous sequences and interfering with transcriptional, translational or epigenetic processes. MiRNAs are involved in a variety of disease processes, and regulate the physiological and pathological status of diseases by modulating target cell activity, migration, invasion, apoptosis, autophagy and other processes. Among them, let-7i is highly expressed in various systems, which participates in the process of tumors, cardiovascular and cerebrovascular diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases and other diseases, and plays a positive or negative regulatory role in these diseases through different signal pathways and key molecules. Moreover, it can be used as an early diagnosis and prognostic marker for a variety of diseases and become a potential therapeutic target. As a biomarker, let-7i is frequently tested in combination with other miRNAs to diagnose multiple diseases and evaluate the clinical treatment or prognosis.
