Role of ceRNA network in inflammatory cells of rheumatoid arthritis.
10.11817/j.issn.1672-7347.2023.220621
- Author:
Xiaoyu HE
1
;
Haohua HE
2
;
Yan ZHANG
3
;
Tianyu WU
4
;
Yongjie CHEN
4
;
Chengzhi TANG
4
;
Tian XIA
3
;
Xiaonan ZHANG
5
;
Changhao XIE
6
Author Information
1. Department of Rheumatology and Immunology, First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004. hexiaoyu365@163.com.
2. Department of Rheumatology and Immunology, First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004.
3. Department of Clinical Medicine, Bengbu Medical College, Bengbu Anhui 233030.
4. School of Public Health, Bengbu Medical College, Bengbu Anhui 233030.
5. Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Bengbu Medical College, Bengbu Anhui 233030. zhangxn@bbmc.edu.cn.
6. Department of Rheumatology and Immunology, First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004. uglboy2002@126.com.
- Publication Type:Journal Article
- Keywords:
circular RNA;
competing endogenous RNA network;
inflammatory cells;
long non-coding RNA;
microRNA;
rheumatoid arthritis
- MeSH:
Humans;
Arthritis, Rheumatoid/genetics*;
MicroRNAs/metabolism*;
Synoviocytes/pathology*;
Cytokines/metabolism*;
RNA, Messenger/metabolism*;
Fibroblasts/pathology*;
Cell Proliferation
- From:
Journal of Central South University(Medical Sciences)
2023;48(5):750-759
- CountryChina
- Language:English
-
Abstract:
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease caused by inflammatory cells. Various inflammatory cells involved in RA include fibroblast-like synoviocytes, macrophages, CD4+T-lymphocytes, B lymphocytes, osteoclasts and chondrocytes. The close interaction between various inflammatory cells leads to imbalance of immune response and disorder of the expression of mRNA in inflammatory cells. It helps to drive production of pro-inflammatory cytokines and stimulate specific antigen-specific T- and B-lymphocytes to produce autoantibodies which is an important pathogenic factor for RA. Competing endogenous RNA (ceRNA) can regulate the expression of mRNA by competitively binding to miRNA. The related ceRNA network is a new regulatory mechanism for RNA interaction. It has been found to be involved in the regulation of abnormal biological processes such as proliferation, apoptosis, invasion and release of inflammatory factors of RA inflammatory cells. Understanding the ceRNA network in 6 kinds of RA common inflammatory cells provides a new idea for further elucidating the pathogenesis of RA, and provides a theoretical basis for the discovery of new biomarkers and effective therapeutic targets.
