Research progress in effects of microRNA -15a and microRNA -16 on fibrotic diseases.
10.11817/j.issn.1672-7347.2023.220129
- Author:
Dada WEN
1
;
Jie WANG
2
Author Information
1. Department of Immunology, School of Basic Medical Science, Central South University, Changsha 410078, China. 2638161421@qq.com.
2. Department of Immunology, School of Basic Medical Science, Central South University, Changsha 410078, China. wj0988@163.com.
- Publication Type:Journal Article
- Keywords:
extracellular matrix;
fibrotic diseases;
inflammation;
microRNA-15a;
microRNA-16
- MeSH:
Humans;
Fibrosis/genetics*;
MicroRNAs/genetics*;
Signal Transduction;
Inflammation
- From:
Journal of Central South University(Medical Sciences)
2023;48(5):743-749
- CountryChina
- Language:English
-
Abstract:
MicroRNA (miR) is a class of highly conserved non-coding single-stranded RNA widely existing in mammals, which can negatively regulate the expression of targeting genes after transcription. As a key regulator, miR negatively regulates the expression of the targeting genes and disrupts important molecular signaling pathways, leading to the imbalance of multiple pathways such as tissue repair and inflammation involved in the fibrotic process. Among them, miR-15a/16 can participate in regulating and controlling the fibrotic process of various organs, including liver, lung, heart, kidney and other fibrotic diseases by acting on cell proliferation and transformation, extracellular matrix proteins production and degradation, inflammation and other important cell functions. It has potential diagnostic and therapeutic value. Clarifying the biological function of miR-15a/16 and its mechanism for action and therapeutic application prospects in various fibrotic lesions are of great significance for the molecular targeted treatment of fibrotic diseases.
