Value for combination of T1WI star -VIBE with TWIST -VIBE dynamic contrast -enhanced MRI in distinguishing lung nodules.
10.11817/j.issn.1672-7347.2023.220588
- Author:
Junjiao HU
1
;
Meitao LIU
2
;
Wei ZHAO
3
;
Ziyan DING
4
;
Fang WU
5
;
Wen HU
6
;
Hu GUO
7
;
Huiting ZHANG
8
;
Pei HU
4
;
Yiyang LI
4
;
Minjie OU
4
;
Danqi HAN
4
;
Xiangyu CHEN
9
Author Information
1. Department of Radiology, Second Xiangya Hospital, Central South University, Changsha 410011. hujujiao91@csu.edu.cn.
2. Department of Radiology, Second Xiangya Hospital, Central South University, Changsha 410011. liumeitaocsu@163.com.
3. Department of Radiology, Second Xiangya Hospital, Central South University, Changsha 410011.
4. Department of Clinical Medicine, Xiangya School of Medicine, Central South University, Changsha 410013.
5. Department of Oncology, Second Xiangya Hospital, Central South University, Changsha 410011.
6. Department of Thoracic Surgery, Second Xiangya Hospital, Central South University, Changsha 410011.
7. MR Application, Siemens Healthineers Ltd, Changsha 410011.
8. MR Scientific Marketing, Siemens Healthineers Ltd, Wuhan 430022, China.
9. Department of Radiology, Second Xiangya Hospital, Central South University, Changsha 410011. chenxiangyu@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
differential diagnosis of lung nodules;
dynamic contrast-enhanced MRI;
lung MRI;
star-VIBE
- MeSH:
Adult;
Humans;
Retrospective Studies;
Magnetic Resonance Imaging;
Plasma;
Tomography, X-Ray Computed;
Lung
- From:
Journal of Central South University(Medical Sciences)
2023;48(4):581-593
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:With the increasing detection rate of lung nodules, the qualitative problem of lung nodules has become one of the key clinical issues. This study aims to evaluate the value of combining dynamic contrast-enhanced (DCE) MRI based on time-resolved imaging with interleaved stochastic trajectories-volume interpolated breath hold examination (TWIST-VIBE) with T1 weighted free-breathing star-volumetric interpolated breath hold examination (T1WI star-VIBE) in identifying benign and malignant lung nodules.
METHODS:We retrospectively analyzed 79 adults with undetermined lung nodules before the operation. All nodules of patients included were classified into malignant nodules (n=58) and benign nodules (n=26) based on final diagnosis. The unenhanced T1WI-VIBE, the contrast-enhanced T1WI star-VIBE, and the DCE curve based on TWIST-VIBE were performed. The corresponding qualitative [wash-in time, wash-out time, time to peak (TTP), arrival time (AT), positive enhancement integral (PEI)] and quantitative parameters [volume transfer constant (Ktrans), interstitium-to-plasma rate constant (Kep), and fractional extracellular space volume (Ve)] were evaluated. Besides, the diagnostic efficacy (sensitivity and specificity) of enhanced CT and MRI were compared.
RESULTS:There were significant differences in unenhanced T1WI-VIBE hypo-intensity, and type of A, B, C DCE curve type between benign and malignant lung nodules (all P<0.001). Pulmonary malignant nodules had a shorter wash-out time than benign nodules (P=0.001), and the differences of the remaining parameters were not statistically significant (all P>0.05). After T1WI star-VIBE contrast-enhanced MRI, the image quality was further improved. Compared with enhanced CT scan, the sensitivity (82.76% vs 80.50%) and the specificity (69.23% vs 57.10%) based on MRI were higher than that of CT (both P<0.001).
CONCLUSIONS:T1WI star-VIBE and dynamic contrast-enhanced MRI based on TWIST-VIBE were helpful to improve the image resolution and provide more information for clinical differentiation between benign and malignant lung nodules.
