Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup.
- Author:
Xiao-Qing LIU
1
;
Run-Shun ZHANG
2
;
Xue-Zhong ZHOU
3
;
Hong ZHOU
4
;
Yu-Yao HE
1
;
Shu HAN
1
;
Jing ZHANG
1
;
Zi-Xin SHU
3
;
Xue-Bin ZHANG
5
;
Jing-Hui JI
3
;
Quan ZHONG
3
;
Li-Li ZHANG
5
;
Zi-Jun MOU
6
;
Li-Yun HE
6
;
Lun-Zhong ZHANG
4
;
Jie YANG
5
;
Yan-Jie HU
1
;
Zheng-Guang CHEN
7
;
Xiao-Zhen LI
7
;
Yan TAN
8
;
Zhan-Feng YAN
9
;
Ke-Gang CAO
1
;
Wei MENG
1
;
He ZHAO
1
;
Wei ZHANG
10
;
Li-Qun ZHONG
11
Author Information
- Publication Type:Journal Article
- Keywords: Chinese medicine; ischemic stroke; patient similarity network; subgroup; syndrome
- MeSH: Humans; Syndrome; Ischemic Stroke; Medicine, Chinese Traditional; Liver; Phenotype
- From: Chinese journal of integrative medicine 2023;29(5):441-447
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To derive the Chinese medicine (CM) syndrome classification and subgroup syndrome characteristics of ischemic stroke patients.
METHODS:By extracting the CM clinical electronic medical records (EMRs) of 7,170 hospitalized patients with ischemic stroke from 2016 to 2018 at Weifang Hospital of Traditional Chinese Medicine, Shandong Province, China, a patient similarity network (PSN) was constructed based on the symptomatic phenotype of the patients. Thereafter the efficient community detection method BGLL was used to identify subgroups of patients. Finally, subgroups with a large number of cases were selected to analyze the specific manifestations of clinical symptoms and CM syndromes in each subgroup.
RESULTS:Seven main subgroups of patients with specific symptom characteristics were identified, including M3, M2, M1, M5, M0, M29 and M4. M3 and M0 subgroups had prominent posterior circulatory symptoms, while M3 was associated with autonomic disorders, and M4 manifested as anxiety; M2 and M4 had motor and motor coordination disorders; M1 had sensory disorders; M5 had more obvious lung infections; M29 had a disorder of consciousness. The specificity of CM syndromes of each subgroup was as follows. M3, M2, M1, M0, M29 and M4 all had the same syndrome as wind phlegm pattern; M3 and M0 both showed hyperactivity of Gan (Liver) yang pattern; M2 and M29 had similar syndromes, which corresponded to intertwined phlegm and blood stasis pattern and phlegm-stasis obstructing meridians pattern, respectively. The manifestations of CM syndromes often appeared in a combination of 2 or more syndrome elements. The most common combination of these 7 subgroups was wind-phlegm. The 7 subgroups of CM syndrome elements were specifically manifested as pathogenic wind, pathogenic phlegm, and deficiency pathogens.
CONCLUSIONS:There were 7 main symptom similarity-based subgroups in ischemic stroke patients, and their specific characteristics were obvious. The main syndromes were wind phlegm pattern and hyperactivity of Gan yang pattern.
