Evaluation of Renal Impairment in Patients with Diabetic Kidney Disease by Integrated Chinese and Western Medicine.

Yi-lun QU; Zhe-yi Dong; Hai-mei Cheng; Qian Liu; Qian Wang; Hong-tao Yang; Yong-hui Mao; Ji-jun LI; Hong-fang Liu; Yan-qiu Geng; Wen Huang; Wen-hu Liu; Hui-di Xie; Fei Peng; Shuang LI; Shuang-shuang Jiang; Wei-zhen LI; Shu-wei Duan; Zhe Feng; Wei-guang Zhang; Yu-ning Liu; Jin-zhou Tian; Xiang-mei Chen

Return

Evaluation of Renal Impairment in Patients with Diabetic Kidney Disease by Integrated Chinese and Western Medicine.

Author: Yi-Lun QU ¹ ; Zhe-Yi DONG ¹ ; Hai-Mei CHENG ¹ ; Qian LIU ^{2
,

3
,

4} ; Qian WANG ¹ ; Hong-Tao YANG ⁵ ; Yong-Hui MAO ⁶ ; Ji-Jun LI ⁷ ; Hong-Fang LIU ⁸ ; Yan-Qiu GENG ⁹ ; Wen HUANG ¹⁰ ; Wen-Hu LIU ¹¹ ; Hui-di XIE ⁸ ; Fei PENG ¹ ; Shuang LI ¹ ; Shuang-Shuang JIANG ¹ ; Wei-Zhen LI ¹ ; Shu-Wei DUAN ¹ ; Zhe FENG ¹ ; Wei-Guang ZHANG ¹ ; Yu-Ning LIU ¹² ; Jin-Zhou TIAN ¹³ ; Xiang-Mei CHEN ¹⁴
Author Information

1. Department of Nephrology, First Medical Center of Chinese People's Liberation Army General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, 100853, China.
2. Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine
3. Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China
4. Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangdong Traditional Chinese Medicine Key Laboratory for Metabolic Diseases, Guangzhou, 510006, China.
5. Department of Nephrology, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.
6. Department of Nephrology, Beijing Hospital, Beijing, 100730, China.
7. Department of Nephrology, The Forth Medical Center of People's Liberation Army General Hospital, Beijing, 100039, China.
8. Department of Endocrinology, Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing, 100700, China.
9. Department of Nephrology, The Third Medical Center of PLA General Hospital, Beijing, 100039, China.
10. Department of Nephrology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
11. Department of Nephrology, Beijing Friendship Hospital, Faculty of Kidney Diseases, Capital Medical University, Beijing, 100050, China.
12. Department of Nephrology, Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing, 100700, China.
13. Three Departments of Encephalopathy, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, 100700, China.
14. Department of Nephrology, First Medical Center of Chinese People's Liberation Army General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, 100853, China. xmchen301@126.com.
Publication Type:Journal Article
Keywords: Chinese medicine syndrome; diabetic kidney disease; integrated Chinese and Western medicine
MeSH: Humans; Male; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Hyperuricemia; Kidney; Proteinuria; Renal Insufficiency, Chronic/complications*
From: Chinese journal of integrative medicine 2023;29(4):308-315
CountryChina
Language:English
Abstract: OBJECTIVE:To investigate the factors related to renal impairment in patients with diabetic kidney disease (DKD) from the perspective of integrated Chinese and Western medicine.
METHODS:Totally 492 patients with DKD in 8 Chinese hospitals from October 2017 to July 2019 were included. According to Kidney Disease Improving Global Outcomes (KDIGO) staging guidelines, patients were divided into a chronic kidney disease (CKD) 1-3 group and a CKD 4-5 group. Clinical data were collected, and logistic regression was used to analyze the factors related to different CKD stages in DKD patients.
RESULTS:Demographically, male was a factor related to increased CKD staging in patients with DKD (OR=3.100, P=0.002). In clinical characteristics, course of diabetes >60 months (OR=3.562, P=0.010), anemia (OR=4.176, P<0.001), hyperuricemia (OR=3.352, P<0.001), massive albuminuria (OR=4.058, P=0.002), atherosclerosis (OR=2.153, P=0.007) and blood deficiency syndrome (OR=1.945, P=0.020) were factors related to increased CKD staging in patients with DKD.
CONCLUSIONS:Male, course of diabetes >60 months, anemia, hyperuricemia, massive proteinuria, atherosclerosis, and blood deficiency syndrome might indicate more severe degree of renal function damage in patients with DKD. (Registration No. NCT03865914).