Evaluation of Renal Impairment in Patients with Diabetic Kidney Disease by Integrated Chinese and Western Medicine.
- Author:
Yi-Lun QU
1
;
Zhe-Yi DONG
1
;
Hai-Mei CHENG
1
;
Qian LIU
2
,
3
,
4
;
Qian WANG
1
;
Hong-Tao YANG
5
;
Yong-Hui MAO
6
;
Ji-Jun LI
7
;
Hong-Fang LIU
8
;
Yan-Qiu GENG
9
;
Wen HUANG
10
;
Wen-Hu LIU
11
;
Hui-di XIE
8
;
Fei PENG
1
;
Shuang LI
1
;
Shuang-Shuang JIANG
1
;
Wei-Zhen LI
1
;
Shu-Wei DUAN
1
;
Zhe FENG
1
;
Wei-Guang ZHANG
1
;
Yu-Ning LIU
12
;
Jin-Zhou TIAN
13
;
Xiang-Mei CHEN
14
Author Information
- Publication Type:Journal Article
- Keywords: Chinese medicine syndrome; diabetic kidney disease; integrated Chinese and Western medicine
- MeSH: Humans; Male; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Hyperuricemia; Kidney; Proteinuria; Renal Insufficiency, Chronic/complications*
- From: Chinese journal of integrative medicine 2023;29(4):308-315
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To investigate the factors related to renal impairment in patients with diabetic kidney disease (DKD) from the perspective of integrated Chinese and Western medicine.
METHODS:Totally 492 patients with DKD in 8 Chinese hospitals from October 2017 to July 2019 were included. According to Kidney Disease Improving Global Outcomes (KDIGO) staging guidelines, patients were divided into a chronic kidney disease (CKD) 1-3 group and a CKD 4-5 group. Clinical data were collected, and logistic regression was used to analyze the factors related to different CKD stages in DKD patients.
RESULTS:Demographically, male was a factor related to increased CKD staging in patients with DKD (OR=3.100, P=0.002). In clinical characteristics, course of diabetes >60 months (OR=3.562, P=0.010), anemia (OR=4.176, P<0.001), hyperuricemia (OR=3.352, P<0.001), massive albuminuria (OR=4.058, P=0.002), atherosclerosis (OR=2.153, P=0.007) and blood deficiency syndrome (OR=1.945, P=0.020) were factors related to increased CKD staging in patients with DKD.
CONCLUSIONS:Male, course of diabetes >60 months, anemia, hyperuricemia, massive proteinuria, atherosclerosis, and blood deficiency syndrome might indicate more severe degree of renal function damage in patients with DKD. (Registration No. NCT03865914).