Progress in Application of Heparin Coating in Blood Contact Medical Devices.
10.3969/j.issn.1671-7104.2023.03.011
- Author:
Tuo YAN
1
;
Weijun YAN
1
Author Information
1. Suzhou Linhwa Medical Devices Co. Ltd., Suzhou, 215000.
- Publication Type:Journal Article
- Keywords:
anticoagulant coating;
heparin coating;
medical device;
surface modification of biomaterial
- MeSH:
Humans;
Heparin/chemistry*;
Anticoagulants/chemistry*;
Thrombosis;
Coated Materials, Biocompatible/chemistry*;
Surface Properties
- From:Chinese Journal of Medical Instrumentation
2023;47(3):288-293
- CountryChina
- Language:Chinese
-
Abstract:
Blood compatibility is the main restriction of blood-contacting medical devices in clinical application, especially long-term blood-contacting medical devices will stimulate the immune defense mechanism of the host, resulting in thrombosis. Heparin anticoagulant coating links heparin molecules to the surface of medical device product materials, improves the compatibility between the material surface interface and the body, and reduces the host immune defense reactions. This study reviews the structure and biological properties of heparin, the market application status of heparin-coated medical products, the insufficiency and improvement of heparin coating, which can provide a reference for the application research of blood contact medical devices.
