Research Progress of Klotho in Lung Neoplasms.
10.3779/j.issn.1009-3419.2023.101.19
- Author:
Jing WANG
1
;
Lili ZENG
2
;
Lingping KONG
2
;
Linlin ZHANG
2
;
Jun CHEN
3
;
Diansheng ZHONG
2
;
Yaguang FAN
1
Author Information
1. Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
2. Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China.
3. Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
- Publication Type:Journal Article
- Keywords:
Klotho;
Lung neoplasms;
Pathogenesis;
Prognosis;
Treatment
- MeSH:
Humans;
Lung Neoplasms;
Carcinogenesis;
Inflammation
- From:
Chinese Journal of Lung Cancer
2023;26(6):473-478
- CountryChina
- Language:Chinese
-
Abstract:
Klotho gene was originally discovered as an anti-aging gene, Klotho protein encoded by Klotho gene is expressed in multiple human tissues, and its most prominent function is the regulation of phosphate homeostasis. Klotho protein possesses various activities, including inhibition of multiple signaling pathways, reducing oxidative stress and suppressing inflammation, and these activities are associated with cancer. Klotho protein is discovered as a universal tumor suppressor, and its expression is associated with tumorigenesis and prognosis of patients. Lung cancer is the most common malignancy tumor, and it is the leading cause of cancer deaths worldwide because of its high incidence and mortality. This article summarizes the research progress of the role of Klotho on pathogenesis, therapeutic effect and prognosis in lung cancer, in order to provide new biomarker and target for diagnosis, treatment and prognosis of lung cancer.
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