Progress in the Study of Spindle Assembly Checkpoint in Lung Cancer.
10.3779/j.issn.1009-3419.2023.101.13
- Author:
Xinchen QIN
1
;
Yao ZHANG
1
;
Haijie YU
1
;
Lijuan MA
1
Author Information
1. Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine,
Macau University of Science and Technology, Macau 999078, China.
- Publication Type:Journal Article
- Keywords:
Aneuploidy;
Mitosis;
Mitotic checkpoint complex;
Spindle assembly checkpoint
- MeSH:
Humans;
Cell Cycle Proteins/metabolism*;
Spindle Apparatus/metabolism*;
Protein Serine-Threonine Kinases/metabolism*;
M Phase Cell Cycle Checkpoints/genetics*;
Lung Neoplasms/metabolism*
- From:
Chinese Journal of Lung Cancer
2023;26(4):310-318
- CountryChina
- Language:Chinese
-
Abstract:
Spindle assembly checkpoint (SAC) is a protective mechanism for cells to undergo accurate mitosis. SAC prevented chromosome segregation when kinetochores were not, or incorrectly attached to microtubules in the anaphase of mitosis, thus avoiding aneuploid chromosomes in daughter cells. Aneuploidy and altered expression of SAC component proteins are common in different cancers, including lung cancer. Therefore, SAC is a potential new target for lung cancer therapy. Five small molecule inhibitors of monopolar spindle 1 (MPS1), an upstream component protein of SAC, have entered clinical trials. This article introduces the biological functions of SAC, summarizes the abnormal expression of SAC component proteins in various cancers and the research progress of MPS1 inhibitors, and expects to provide a reference for the future development of lung cancer therapeutic strategies targeting SAC components.
.
